Interleukin-12 (IL-12), produced by dendritic cells in response to activation, is central to pathogen eradication and tumor rejection.The trafficking pathways controlling spatial distribution and intracellular transport of IL-12 vesicles to the cell surface are still unknown.Here, we show that intracellular IL-12 localizes in late endocytic vesicle
Analysis of the time-dependent behavior of the buoyant plume rising above Grotto Vent (Main Endeavour Field, Juan de Fuca Ridge) as imaged by the Cabled Observatory Vent Imaging Sonar (COVIS) between September 2010 and October of 2015 captures long term time-dependent changes in the direction of background bottom currents independent of broader oce
ABSTRACT Objective: To map the educational technologies implemented for HIV prevention in black people.Method: Scope review, performed according to the recommendations of The Joanna Briggs Institute, in Medline/PubMed, Embase, LILACS, CINAHL, Scopus, Cochrane and PsycINFO databases, using the read more Preferred Reporting Items for Systematic revie
Abstract Background Cognitive behavioral therapy for insomnia (CBT-I) is a highly effective nonpharmacological intervention that is widely considered the gold standard for insomnia treatment.Insomnia is a prevalent and debilitating public health concern.Up to one third of the general population struggles with chronic insomnia, greatly increasing th